Sermorelin (10 mg Vial) Dosage Protocol
Research guide for gradual escalation dosing and reconstitution procedures for Sermorelin, a synthetic GHRH analog investigated for endogenous pituitary GH secretion stimulation.
Quickstart Highlights
Sermorelin operates as a synthetic growth hormone-releasing hormone (GHRH) analog that stimulates endogenous pituitary GH secretion. Originally authorized for pediatric growth hormone deficiency, it is investigated for adult off-label use to support physiologic GH output and IGF-1 levels. Administration via once-daily subcutaneous injection at bedtime synchronizes with natural nocturnal GH release patterns.
- Reconstitute: Add 3.0 mL bacteriostatic water → approximately 3.33 mg/mL concentration
- Weekly dosing schedule: 200 µg → 300 µg → 400 µg → 500 µg over 8 weeks
- Easy measuring: At 3.33 mg/mL, 1 unit on U-100 insulin syringe ≈ 33.3 µg
- Storage: Refrigerate reconstituted solution at 2–8 °C, use within 10–14 days
Dosing & Reconstitution Guide
Standard Daily Titration Protocol
Daily Subcutaneous Protocol (3 mL = ~3.33 mg/mL)
| Week | Daily Dose | Units (per injection) | mL per injection |
|---|---|---|---|
| 1–2 | 200 µg (0.2 mg) | 6 units | 0.06 mL |
| 3–4 | 300 µg (0.3 mg) | 9 units | 0.09 mL |
| 5–6 | 400 µg (0.4 mg) | 12 units | 0.12 mL |
| 7–8 | 500 µg (0.5 mg) | 15 units | 0.15 mL |
Administration: Once daily subcutaneously at bedtime. Typical adult research range: 200–500 µg daily with gradual titration.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe
- Inject slowly down the vial wall; gently swirl to dissolve (do not shake vigorously)
- Label with reconstitution date and refrigerate at 2–8 °C (36–46 °F), protected from light
- Wipe vial stopper with alcohol before each use; use a new sterile needle and syringe for each injection
Result: Approximately 3.33 mg/mL concentration, allowing 1 unit on a U-100 insulin syringe to equal approximately 33.3 µg
Storage Guidelines
- Lyophilized: −20 °C (−4 °F), dry/dark conditions
- Reconstituted: 2–8 °C (35.6–46.4 °F); do NOT freeze
- Shelf life: 28 days post-reconstitution
Key Administration Notes
- Rotate injection sites to prevent lipohypertrophy
- Gastrointestinal effects common initially; titration minimizes them
- Document weekly dose, date, and injection site
- Use sterile syringes; dispose in sharps container
- Allow vials to reach room temperature before opening
⚠️ Research & Educational Purposes Only
This information is provided for research and educational purposes only. Peptides discussed are intended for laboratory research use only and are not approved for human consumption. Always consult qualified healthcare professionals for medical advice. Individual results may vary. This is not medical advice.