Selank (10 mg Vial) Dosage Protocol
Reconstitution and dosing guide for the 10 mg Selank vial — a synthetic tuftsin-derived anxiolytic and nootropic peptide, prepared at 5 mg/mL for smaller dose volumes. Most commonly administered intranasally.
Quickstart Highlights
Selank is a synthetic peptide derived from the immunomodulatory peptide tuftsin, researched for anxiolytic (anti-anxiety) and nootropic effects without the sedation or dependence associated with conventional anxiolytics. It is thought to influence GABAergic and serotonergic signaling and to modulate BDNF and enkephalin activity. It is most often administered intranasally, with subcutaneous use also reported.
- Composition: 10 mg Selank per vial
- Reconstitute: Add 2.0 mL bacteriostatic water → 5 mg/mL concentration
- Easy measuring: At 5 mg/mL, 1 unit (0.01 mL) on a U-100 syringe = 50 mcg
- Storage: Lyophilized: −20 °C (−4 °F); reconstituted: 2–8 °C (35.6–46.4 °F), protected from light, use within 2–4 weeks
Dosing & Reconstitution Guide
Daily protocol — most often intranasal; the volumes below apply to either intranasal drops or subcutaneous injection
Protocol (10 mg vial, 2 mL = 5 mg/mL)
| Phase | Daily Dose | Per-dose Volume | Units (U-100) |
|---|---|---|---|
| Standard | 250 mcg, 1–2× daily | 0.05 mL | 5 units |
| Higher | 500 mcg daily | 0.10 mL | 10 units |
Administration: Most commonly intranasal — apply measured drops divided between the nostrils; it may also be given subcutaneously. The short half-life favors 1–2 doses per day.
Reconstitution Steps
- Allow the vial to reach room temperature (15–20 minutes out of cold storage).
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall to avoid foaming.
- Gently swirl or roll until fully dissolved (do not shake).
- Label with date and concentration; refrigerate at 2–8 °C, protected from light.
- For intranasal use, draw the measured volume into a sterile dropper or nasal applicator instead of an injection syringe.
Result: 5 mg/mL concentration
How This Works
Selank is a stabilized analog of tuftsin (a fragment of the immunoglobulin G molecule). Research associates it with modulation of GABAergic and serotonergic neurotransmission, changes in the expression of brain-derived neurotrophic factor (BDNF), and inhibition of enkephalin breakdown — a profile linked to reduced anxiety and improved stress resistance.
Unlike benzodiazepines, it is not reported to cause sedation, tolerance, or withdrawal in the research literature. Effects are relatively short-acting, so dosing is typically once or twice daily.
Key Administration Notes
- Most research use is intranasal; keep applicators clean and dedicated.
- Short half-life favors 1–2 doses per day.
- If injecting, rotate sites and use new sterile syringes; dispose in a sharps container.
- Document dose, route, and timing for consistency.
References
Zozulia AA, et al. Efficacy and safety of the anxiolytic Selank in generalized anxiety disorder and neurasthenia. View Source
Kozlovskaya MM, et al. Selank and short peptides of the tuftsin family in anxiety regulation. View Source
⚠️ Research & Educational Purposes Only
This information is provided for research and educational purposes only. The compounds discussed are intended for laboratory research use only and are not approved for human consumption. Always consult qualified healthcare professionals for medical advice. Individual results may vary. This is not medical advice.